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Showing posts with label dog cancer. Show all posts
Showing posts with label dog cancer. Show all posts

Should I Neuter My Dog? The Shocking Risks Of Neutering Early

Intact male dogs tend to live longer healthier lives
Image: Courtesy of PublicDomainImages.net
Images of frightened, discarded cats and dogs in shelters tug at our hearts and serve to encourage the public to embrace the spaying and neutering of pets as a way to reduce the unwanted pet population. 

The burgeoning population of abandoned cats and dogs has increased in tough economic times. A growing trend in the animal welfare and rescue community has been to spay and neuter cats and dogs prior to releasing their charges to their new adoptive families.  

In the case of young kittens and puppies, some of the more zealous of these organizations have begun spaying and neutering puppies as early as 6 -8 weeks of age.  

Research regarding the long term benefits and risks that such early intervention may have on the physical development of the adult dog is many years away. However we can look to existing research for the effects on the health of dogs spayed or neutered prior to one year of age.  The surprising results of these studies inform the advisability of altering male dogs as well as the age that spay or neuter may be appropriate.

In 2007, Laura J. Sanborn, M.S. published a study, “Long-Term Health Risks and Benefits Associated with Spay / Neuter in Dogs.”  This study reviewed much of the existing veterinary medical literature, over 50 peer-reviewed articles, in an attempt to access the health impacts of spaying and neutering dogs, and to aid veterinary care providers and pet owners in making more informed decisions regarding the advisability of spay / neuter as well as appropriate timing in the dog’s development for surgery.

The Health Benefits and Risks of Neutered Male Dogs

Veterinarians regularly tout the health benefits associated with neutering male puppies.  Reduction of prostate cancer is frequently cited as a benefit, additionally prevention of testicular cancer is also cited as an important consideration in the long term health of the dog.  While neutering will eliminate the risk of dying from testicular cancer, the risk of developing this cancer and dying from it, for an intact dog, is less than one percent. And while prostate cancer in humans is linked to testosterone, studies show that in canines it appears to have an opposite effect on them than it does on humans.

Benefits of neutering found in a review of the medical studies included moderate reduction in the likelihood of males developing:
  • perianal fistulas
  • non-cancerous prostate disorders
  • and possibly a reduction in the risk of developing diabetes
While the benefits associated with neutering males in this study appear minimal, the increased risk of developing several cancers, obesity, orthopedic disorders and adverse reactions to vaccinations is substantial.

Risks: Neutered Male Dogs vs. Intact Males:
  • Neutered males are 1.6 times more likely to develop Cardiac Hemangiosarcoma than their intact counter parts.
  • Are twice as likely to develop Urinary Tract Cancer than intact males
  • Are four times more likely to develop Prostate Cancer than intact males.
  • Experience a 27% increase in adverse reactions to vaccinations over their intact counterparts.
  • And if neutering is done prior to 1 year of age, it substantially increases the risk of the more common cancer Osteosarcoma (bone cancer)
Additionally, neutered dogs are 4 times more likely to be obese than their intact counterparts, in fact neutering triples the risks of hypothyroidism, which causes weight gain, lethargy and hair loss.  

Perhaps due to being overweight, neutered dogs also experience a higher risk of developing orthopedic disorders and are at greater risk for progressive geriatric cognitive impairment.

Weighing the benefits against the increased health risks associated with neutering male dogs, it appears from this study that the risks far outweigh the benefits, with one major exception. Unilateral and bilateral cryptorchism, or undescended testicles,when not neutered, results in a 13 times greater chance of developing testicular cancer.  While prognosis for treatment of testicular cancer is good, a 90% cure rate, it is advisable to neuter these dogs. 

Marking behavior normally occurs when 
there are intact females in the home
 Courtesy of PublicDomainImages.net

Marking Indoors

Many owners wish to eliminate the tendency of male dogs to mark territory, by neutering males before they reach sexual maturity.  In fact males neutered around 6 months of age frequently never learn to “hike” their legs, and eliminate in the same manner as puppies and female dogs do. 

However, with proper training, males will learn not to mark or hike their legs indoors.  It is only when males are exposed to intact females and their estrus cycle, that the male marking behavior becomes a challenge inside the home.

Aggression Reduction

Another reason cited for neutering males is to reduce or eliminate aggressive behavior. Intact dogs are not welcome at dog parks and for good reason.  A pair of intact males presented with an intact female in estrus will likely result in a display of aggression between the males. 

Dominant males will want to assert themselves, and the cost to your dog's health and your wallet are not worth the risk.  If you are keeping an intact male dog, respect the rules of dog parks and most municipal and county laws. Keep your dog on leash or confined at all times.

Total Lifespan Intact vs. Neutered Males

In a recent study at University of Georgia, researchers examined records of over 40,000 dogs to determine whether intact males or neutered males live longer.  While they too found that neutered males tend to die of certain cancers at a higher rate than their intact counterparts, overall the neutered dogs had, on average, a longer lifespan.  The study showed that intact males and females tended to die more frequently of infectious disease at an earlier age than the spayed and neutered dogs in the study.

It should be noted that the dogs in this study were from teaching hospitals, and the results might be different in private veterinary practices.  It is not known whether the intact males and females were pets or strays and what level of care they had received prior to admission. 

Courtesy of PublicDomainImages.net
Should We Neuter Our Dog?

If you have a breed that is predisposed to developing certain cancers such as osteosarcoma, lymphoma or hemangiosarcomo, and you have a well fenced yard, you may want to leave your male intact.  

The research clearly shows that the earlier that you spay or neuter your pet, they greater the risk is of developing one of the aforementioned cancers.

However, recent research also suggests that neutered males live longer than intact males. If you opt for neutering, we suggest that you wait until your dog’s first birthday to alter him.  While many vets advocate neutering at 6 months, it appears that hormones from the reproductive system are aiding in the development of the dog’s autoimmune system. Allowing him to reach sexual maturity will give him the advantage that these hormones provide, and hopefully extend his lifespan as well as the quality of his final years.

4 Promising Studies: Early Detection and Treatment Options for Canine Hemangiosarcoma

Courtesy of Public Domain Images
Hemangiosarcoma is a form of cancer found almost exclusively in dogs. A relatively common canine cancer (6-8% of all canine cancers) it is estimated that 2 million of 73 million dogs currently alive in the United States will develop the disease and die from it.

At this time, it is considered incurable, as it remains symptomless until the advanced stages of the disease.  The current standard of care, surgery and chemotherapy, have proven to extend the life to the affected dog a mere median of 180 days with surgery alone, and an additionally 180 days with chemotherapy added to surgical intervention.

In the wake of these poor treatment outcomes, research has focused on early detection of the disease as well as a new, very promising alternative medicine approach.

Hemangiosarcoma

Hemangiosarcoma is an indolent cancer, meaning it initially develops very slowly, asymptomatically and painlessly.  The most common primary sites of the disease are the spleen, right atrium of the heart and the tissue beneath the skin.  In the later stages of the disease, the cancer aggressively metastasizes to the lungs, liver and intestines.   While dogs of any age and breed may be susceptible to hemangiosarcoma, it occurs more commonly in dogs beyond middle age, and has a higher incidence in breeds such as German Shepherd Dogs, Golden Retrievers, Portuguese Water Dogs and Skye Terriers, suggesting a genetic component is involved.

The Canine Genome

The completion of the Canine Genome Project has spurred research into the genetic components of a wide variety of physical ailments believed to have heritable factors. Researchers at Modiano Lab at the University of Minnesota have taken an interest in the genetic components contributing to hemangiosarcoma.   Three of the more promising approaches involve mapping the risk alleles associated with the disease, determining the genetic, breed-specific abnormalities of the tumors themselves and developing a blood test for early detection of cancer cells via flow cytology.

The first project, developed in collaboration with Dr. Matthew Breen, focused on the possibility of breed specific abnormalities that may be detectable in tumors arising in dogs of different breeds. The initial results were promising; the data showed that tumors from dogs of one specific breed are functionally and genetically more similar to each other than they are to tumors from dogs of other breeds. This information demonstrates that heritable risk factors contribute to the development of canine cancer. More importantly, these results are the first step toward developing prevention and treatment strategies that address the specific causes underlying the biology of canine hemangiosarcoma.

The second project of great promise, developed in collaboration with the National Human Genome Research Institute of the National Institutes of Health and the Broad Institute of MIT and Harvard, has begun the process of mapping the risk alleles for the development of both Lymphoma and Hemangiosarcoma in the following target breeds:

Turkey Tail Fungus - Penn State's Magic Mushrooms see below
Courtesy of Wallwork Family Pages

  • Australian Shepherd
  • Bernese Mountain Dog
  • Border Collie
  • Boxer
  • Briard
  • Bullmastiff
  • Cocker Spaniel
  • Flat-coated Retriever
  • German Shepherd Dog
  • Golden Retriever
  • Greyhound
  • Irish Setter
  • Keeshond
  • Labrador Retriever
  • Mastiff
  • Poodle
  • Portuguese Water Dog
  • Rottweiler
  • Vizsla
  • Saluki
Researchers are currently seeking samples for this research in the form of blood samples and tumor samples with associated pedigree information.  Samples from mixed breeds and other breeds are welcome from both healthy (aged) dogs and affected dogs.  To learn more about how to contribute to the project visit the Modiano Labs website.

Early Cancer Detection: Flow Cytometry

Once we have a genetic test that can forewarn us of a genetic predisposition to developing specific cancers, we will want to be able to detect the disease at an early stage of its development, well before it becomes symptomatic.

As cancer tumors grow, they shed cells into the blood stream.  However, the tumor cells are shed so infrequently that they cannot be detected in routine blood tests. Enter the technology called flow cytometry. Here cells are “tagged” with fluorescent molecules that identify their lineage of origin, they are then run through an instrument (the flow cytometer) that combines optics and fluidics information through a software capable of analyzing hundreds of thousands of cells in a matter of minutes.

Researchers have employed this technology, and have successfully shown proof of principle for this test. Idexx Laboratories has licensed the technology from the University of Colorado, although the ultimate affordability of employing this technology in local veterinary practices tests remains to be seen.  Another issue with this technology, is that it does not tell us where the site of origin of the tumor is. Early treatment will therefore need to be able to treat the disease independent of the site of origin.

The Biggest Breakthrough In Hemangiosarcoma Cancer Treatment: Penn State’s Magic Mushrooms

In a Penn State study funded by Chinese Medicine Holding LTD. and released in September 2012, dogs with hemangiosarcoma were treated with a compound derived from the Coriolus Versicolor mushroom, resulting in the longest survival times ever reported for dogs with the disease.

The Coriolus Versicolor mushroom, known commonly as the Yunzhi mushroom, has been used in traditional Chinese medicine for over 2,000 years. A compound within the mushroom, polysaccharopeptide, or PSP, is believed to have immune-boosting properties. Over the past two decades, studies have indicated that PSP may also have a tumor-fighting effect.

Penn State researchers studied dogs with naturally occurring hemangiosarcoma to see what effects, the Yunzhi mushroom would have on their patients. Fifteen dogs that had been diagnosed with hemangiosarcoma participated in the trial. Divided into three groups of five, each group received a different dose — 25, 50 or 100 mg/kg/day — of I’m-Yunity, a formulation of PSP which is also readily available over the Internet. The dog owners were instructed to give their dog a capsule of I’m-Yunity, daily. The owners brought their dogs to Penn’s Ryan Veterinary Hospital for follow-up visits on a monthly basis for blood sample testings and ultrasounds to determine the extent that tumors had developed or spread in the dogs’ bodies.

“We were shocked,” Cimino Brown said of Penn State. “Prior to this, the longest reported median survival time of dogs with hemangiosarcoma of the spleen that underwent no further treatment was 86 days. We had dogs that lived beyond a year with nothing other than this mushroom as treatment.”

Not only had the dog’s survival times increased with the use of PSP, but unlike chemotherapy, there were no reported side effects.  Dogs receiving the highest dosage, 100 mg/day, had the longest median survival time, however the difference in survival times between dosages was not statistically significant.

While not inexpensive, this treatment is certainly more affordable than chemotherapy.  Those on tight budgets, may consider using this supplement at the lower dosage without fear of significantly impacting survival rates.  However, it should be noted that while the PSP, I’m Yunity, extends life and improves quality of life, it has not been shown to be a cure for hemangiosarcoma.

The Penn State researchers are preparing to pursue further trials of I’m-Yunity in dogs with hemangiosarcoma to confirm and refine their results. One upcoming trial will compare I’m-Yunity to a placebo for those owners who choose not to pursue chemotherapy for their pet; the other will compare the compound with the current standard-of-care, chemotherapy.

Here are some options for Organic Turkey Tail Mushroom Extract 

 

The liquid form may be easier to administer.  The capsules are 500mg, so you would need to open the capsule and shake out 1/4 of the mushroom extract. For larger dogs (80 lbs and up) you may want to give them one third of a capsule or approximately 165mg.

We will keep you posted as more information comes in from the ongoing Penn State Research.

For information on Canine Osteosarcoma please click here.

15 Warning Signs of Cancer in Dogs



Cancer is increasingly common in pet animals, and as pets age, the likelihood of contracting some form of the disease increases substantially.  In fact, cancer accounts for almost half of the deaths of pets over 10 years of age. 

In breeds like the golden retriever it is estimated that between 60 and 80% will contract a form of cancer. But cancer is not restricted to geriatric canines, dogs as young as 4 years old may be diagnosed with it.

While dogs in general contract cancer at approximately the same rate as humans; cats tend to get fewer cancers, perhaps owing to their nine lives. Some cancers such as Hemangiosarcom and Oesteosarcoma have a higher rate of occurrence within certain breeds, suggesting a genetic component is probably at work.

If your dog’s breed has a propensity for developing a specific type of cancer, it is a good idea to familiarize yourself with the early warning symptoms of the onset of the disease.  Awareness of the signs of cancer in dogs combined with early detection and quick action can significantly improve the outcome for your pet.

sleeping senior dog
By Darnyi Zsóka via Wikimedia Commons

Common Warning Signs of Cancer in Dogs

If you suspect a combination of the following symptoms in your pet, consult your veterinarian promptly; when it comes to the health of your pet, it is always better to be safe now than sorry later.

  1. Foul Odors from the Mouth or Other Orifices: Foul Odors from the Mouth: If you detect offensive odors emanating from your dog’s mouth, and there has been no change in diet, you should have it checked out. Halitosis combined with excessive drooling, difficulty eating or swallowing can be a sign of oral cancer.   Bloody saliva indicates a prompt visit to the vet is in order. Bad odors from the ears, anal area or any other part of your pet’s body, should be checked out as well.  While food allergies, mites, impacted anal glands, infections from bites or scrapes or yeast infections can cause foul odors, it is best to seek veterinary advice to clear up any of these conditions and check for the underlying cause of the odor.
  2. Nasal discharge. This can be a sign of allergies, or especially if discolored or bloody, a symptom of cancer of the nasal and sinus cavities.
  3. Excessive Drooling and Difficulty Eating or Swallowing.  Excessive drooling, especially combined with a strong halitosis merits further investigation.  Anytime a dog has difficulty eating or swallowing you should consult a veterinarian immediately.  
  4. Difficulty Breathing and Coughing. Dogs having difficulty breathing  should be examined immediately.  For both humans and dogs, shortness of breath is a critical symptom.  Heart disease, lung cancer and hemangiosarcoma are potential underlying causes of breathing difficulties.  Early detection of any of these diseases can improve your dog’s prognosis.
  5. Excessive Panting.  It is normal for dogs to pant following exercise (for 20-30 minutes) or in extremely warm conditions.  Prolonged panting however may be a symptom of a severe injury or chronic illness such as heart failure, Cushing's syndrome, pneumonia or lung tumors.  
  6. Loss of Appetite. Dogs usually do not stop eating without a cause.  If your dog suddenly loses his appetite and there has been no change in diet, you should consider a trip to the vet, particularly if it is combined with some of the other symptoms on this list.  While this may not be a symptom of cancer, it could be a symptom of another serious issue where early intervention is beneficial.
  7. Lethargy. Lack of stamina or fatigue developing over a relatively short time frame can be symptoms of cancer.  Beyond normal aging, a dog that over a period of weeks or months that exhibits a noticeable decrease in activity levels should be seen by your veterinarian.  Other possible causes of lethargy and lack of appetite can include parasites such as tapeworms, roundworms, hookworms and whipworms, conditions that you will also want to address quickly.
  8. Depression.  You can’t put your finger on it, but Rover just doesn't seem to be himself.  Depressed dogs don’t seem to take pleasure in their usual activities; they tend to lie down away from the family activities exhibiting a decreased interest in their surroundings.  This can be a symptom of a change in the family dynamic or environment, but if there have been no changes to the family routine, depression combined with a several other symptoms on this list should be noted when discussing your dog’s health with your veterinarian.
  9. Changes in Bathroom Habits. A dog that is normally well house trained begins soiling the house (and there have been no changes in the household dynamics to upset him) or the consistency of the bowel movement is unusual.  This symptom combined with depression were our first clues that something was wrong with our dog Kebe, prior to her being diagnosed with a branching cancerous tumor. Additionally, difficulty using the bathroom, frequent bathroom use or blood in urine or stool are all symptoms indicating a prompt visit to your vet is in order.
  10. Abdominal Distention. If your dog’s abdomen becomes bloated or distended it could be a sign of an accumulation of abnormal discharge within the body. Accumulation of fluids can be indicative of congestive heart failure and cardiac hemangiosarcoma.
  11. Lameness or Difficulty Walking.  Sudden onset of lameness or pain during exercise, when the dog has not engaged in any extreme physical activities can be indicative of arthritis or bone cancer (osteosarcoma).
  12. Weight Loss:  Just as in humans, cancer can cause its victims to lose weight dramatically.  If your pet has experienced weight loss, and you have not adjusted caloric intake or increased activity levels of your pet, then a trip to the vet is indicated.  If you notice sudden weight loss in your dog, along with other signs from this list (especially weight loss combined with decreased activity levels), be sure to mention it to your veterinarian.
  13. Vomiting or Diarrhea.  Vomiting and/or excessive diarrhea that continue for more than a day should be checked out by a vet.  At the very least, the dog may become dehydrated, a condition easily remedied by administration of fluids.  Prolonged vomiting or the inablility to hold down fluids and solids can indicate pancreatitis, kidney disease or digestive cancer.
  14. Lumps That are Unresolved or Growing. Not all lumps on or under your dog’s skin will be cancerous, but they are a cause for concern.  If the lump is growing rapidly, is ulcerated or bleeding, warm or painful to the touch you should consult your veterinarian. While it may just be a cyst, your vet can perform a needle biopsy and a veterinary pathologist can determine if the cells are cancerous or not.
  15. Sores That Don’t Heal. If your pet has wounds or sores that are not healing, it could be a sign of infection, skin disease, diabetes or cancer.
While many items on this list, when exhibited individually, are not cause for concern, an accumulation of 3 or more of these symptoms is reason to visit your veterinarian.

As your pet ages, it is a good idea to routinely examine him by stroking and petting his entire body. Tummy rubs and scratching around the ears and neck can aid in detecting any unusually bumps, and your dog will enjoy it too.  An annual physical examination along with annual laboratory analysis (for elderly pets) can be useful in early detection of a variety of disorders including those that affect the kidney, liver, heart or bowel.